Research Articles – BRASS Study

2023

McCarter KR, Arabelovic S, Wang X, et al. Immunomodulator use, risk factors and management of flares, and mortality for patients with pre-existing rheumatoid arthritis after immune checkpoint inhibitors for cancer. Semin Arthritis Rheum. Published online December 8, 2023. doi:10.1016/j.semarthrit.2023.152335. Abstract.

Kronzer VL, Hayashi K, Yoshida K, et al. Autoantibodies against citrullinated and native proteins and prediction of rheumatoid arthritis-associated interstitial lung disease: A nested case-control study. Lancet Rheumatol. 2023;5(2):e77-e87. doi:10.1016/s2665-9913(22)00380-0. Abstract.

Maica GL, Iannaccone C, Feathers V, Frits ML, Bykerk VP, Bingham CO, Weinblatt M, Shadick NA. Understanding Differences in Patient Descriptions of Rheumatoid Arthritis Flares Using OMERACT Core Domains. J Rheumatol. 2023;50(7):889-894. doi:10.3899/jrheum.211409. Abstract.

Anderson RJ, Cui J, Weinblatt ME, Solomon DH, Naik C, Shadick NA. Patterns of Involvement of the Hand Joints in Classical Rheumatoid Arthritis. J Clin Rheumatol. 2023;29(5):230-234. doi:10.1097/RHU.0000000000001971. Abstract.

Shadick N, Hagino O, Praestgaard A, Fiore S, Weinblatt M, Burmester G. Association of hemoglobin levels with radiographic progression in patients with rheumatoid arthritis: an analysis from the BRASS registry. Arthritis Res Ther. 2023;25(1):88. Published 2023 May 27. doi:10.1186/s13075-023-03068-w. Full Text.

2022

Zhuo J, Xia Q, Sharma N, Gao S, Lama S, Cui J, Feathers V, Shadick N, Weinblatt ME. The Role of Shared Epitope in Rheumatoid Arthritis Prognosis in Relation to Anti-Citrullinated Protein Antibody Positivity. Rheumatol Ther. 2022 Apr;9(2):637-647. doi: 10.1007/s40744-022-00427-y. Epub 2022 Feb 16. PMID: 35174462; PMCID: PMC8964857. Abstract

Felson D, Feathers V, Naik C, Solomon DH, Weinblatt ME, Shadick N. Meaning of patient global assessment when joint counts are low in rheumatoid arthritis. RMD Open. 2022;8(2):e002346. doi:10.1136/rmdopen-2022-002346. Full Text.

Wu X, Jeong Y, Poli de Frías S, et al. Serum proteomic profiling of rheumatoid arthritis-interstitial lung disease with a comparison to idiopathic pulmonary fibrosis. Thorax. 2022;77(10):1041-1044. doi:10.1136/thorax-2021-217822. Full Text.

McDermott G, Gill R, Gagne S, Byrne S, Huang W, Cui J, Prisco L, Zaccardelli A, Martin L, Kronzer VL, Moll M, Cho MH, Shadick N, Dellaripa PF, Doyle T, Sparks JA. Associations of the MUC5B promoter variant with timing of interstitial lung disease and rheumatoid arthritis onset. Rheumatology (Oxford). 2022;61(12):4915-4923. doi:10.1093/rheumatology/keac152. Full Text.

2021

Curtis JR, Weinblatt ME, Shadick NA, Brahe CH, Østergaard M, Hetland ML, Saevarsdottir S, Horton M, Mabey B, Flake DD 2nd, Ben-Shachar R, Sasso EH, Huizinga TW. Validation of the adjusted multi-biomarker disease activity score as a prognostic test for radiographic progression in rheumatoid arthritis: a combined analysis of multiple studies. Arthritis Res Ther. 2021 Jan 4;23(1):1. doi: 10.1186/s13075-020-02389-4. PMID: 33397438; PMCID: PMC7784276. Abstract

Curtis JR, Weinblatt M, Saag K, Bykerk VP, Furst DE, Fiore S, St John G, Kimura T, Zheng S, Bingham CO 3rd, Wright G, Bergman M, Nola K, Charles-Schoeman C, Shadick N. Data-Driven Patient Clustering and Differential Clinical Outcomes in the Brigham and Women’s Rheumatoid Arthritis Sequential Study Registry. Arthritis Care Res (Hoboken). 2021 Apr;73(4):471-480. doi: 10.1002/acr.24471. Epub 2021 Mar 13. PMID: 33002337; PMCID: PMC8048846. Abstract

Kremer JM, Pappas DA, Kane K, Greenberg J, Harrold LR, Feathers VL, Shadick N, Weinblatt ME, Reed G. The Clinical Disease Activity Index and the Routine Assessment of Patient Index Data 3 for Achievement of Treatment Strategies. J Rheumatol. 2021 Dec;48(12):1776-1783. doi: 10.3899/jrheum.200692. Epub 2020 Dec 15. PMID: 33323534. Abstract

Kronzer, V. L., Huang, W., Dellaripa, P. F., Huang, S., Feathers, V., Lu, B., … & Sparks, J. A. (2021). Lifestyle and clinical risk factors for incident rheumatoid arthritis-associated interstitial lung disease. The Journal of Rheumatology, 48(5), 656-663. Abstract

Weber B, He Z, Yang N, Playford MP, Weisenfeld D, Iannaccone C, Coblyn J, Weinblatt M, Shadick N, Di Carli M, Mehta NN, Plutzky J, Liao KP. Divergence of Cardiovascular Biomarkers of Lipids and Subclinical Myocardial Injury Among Rheumatoid Arthritis Patients With Increased Inflammation. Arthritis Rheumatol. 2021;73(6):970-979. doi:10.1002/art.41613. Full Text.

Esposito AJ, Sparks JA, Gill RR, Hatabu H, Schmidlin EJ, Hota PV, Poli S, Fletcher EA, Xiong W, Frits ML, Iannacone CK, Prado M, Zaccardelli A, Marshall A, Dellaripa PF, Weinblatt ME, Shadick NA, Rosas IO, Doyle TJ. Screening for preclinical parenchymal lung disease in rheumatoid arthritis. Rheumatology (Oxford). 2022;61(8):3234-3245. doi:10.1093/rheumatology/keab891. Full Text.

2020

Huang S, Doyle TJ, Hammer MM, Byrne SC, Huang W, Marshall AA, Iannaccone CK, Huang J, Feathers V, Weinblatt ME, Dellaripa PF, Shadick NA, Sparks JA. Rheumatoid arthritis-related lung disease detected on clinical chest computed tomography imaging: Prevalence, risk factors, and impact on mortality. Semin Arthritis Rheum. 2020 Dec;50(6):1216-1225. doi: 10.1016/j.semarthrit.2020.08.015. Epub 2020 Sep 28. PMID: 33059295; PMCID: PMC7736489. Abstract

Mahmoud TG, Huang J, Frits M, Iannaccone CK, Bykerk V, Bingham III CO, Weinblatt ME, Shadick NA. Correlates of Successful Rheumatoid Arthritis Flare Management: Clinician-driven Treatment, Home-based Strategies, & Medication Change. The Journal of Rheumatology. 2020 Jan 6. doi: 10.3899/jrheum.181160. Abstract

Alemao E, Bao Y, Weinblatt ME, Shadick N. Association of Seropositivity and Mortality in Rheumatoid Arthritis and the Impact of Treatment With Disease-Modifying Antirheumatic Drugs: Results From a Real-World Study. Arthritis Care Res (Hoboken). 2020;72(2):176-183. doi:10.1002/acr.24071. Full Text.

2019

Alemao E, Iannaccone CK, Weinblatt ME, Shadick NA. Association of Changes in Anticitrullinated Protein Antibody Levels With Resource Use and Disease Activity Measures in Rheumatoid Arthritis Patients a US Observational Cohort. Clin Ther. 2019 Jun;41(6):1057-1065.e3. doi: 10.1016/j.clinthera.2019.04.029. Epub 2019 May 23. Abstract

Curtis JR, Brahe CH, Østergaard M, Hetland ML, Hambardzumyan K, Saevarsdottir S, Wang X, Flake II DD, Sasso EH, Huizinga TW. Predicting Risk of Radiographic Progression for Patients with Rheumatoid Arthritis: Comparative Analysis of the Multi-biomarker Disease Activity Score and Conventional Measures of Disease Activity in Multiple Studies. Current Medical Research and Opinion. 2019 Feb 19. doi: 10.1080/03007995.2019.1585064. Abstract

Curtis JR, Flake DD, Weinblatt ME, Shadick NA, Østergaard M, Hetland ML, Brahe CH, Hwang YG, Furst DE, Strand V, Etzel CJ. Adjustment of the multi-biomarker disease activity score to account for age, sex and adiposity in patients with rheumatoid arthritis. Rheumatology (Oxford). 2019 May 1;58(5):874-883. doi: 10.1093/rheumatology/key367. PMID: 30590790; PMCID: PMC6477524. Abstract

Curtis JR, Weinblatt ME, Saag K, Bykerk V, Charles-Schoeman C, Fiore S, St. John G, Kimura T, Zheng S, Bingham C, Wright G, Bergman M, Nola K, Furst DE, Shadick NA Exploring Heterogeneity in Rheumatoid Arthritis: Patient Profiling Through Principal Component and Cluster Analysis of the BRASS Registry. Annals of the Rheumatic Diseases. 2019 June 13. http://dx.doi.org/10.1136/annrheumdis-2019-eular.541. Abstract

Feldman CH, Yoshida K, Xu C, Frits ML, Shadick NA, Weinblatt ME, Connolly SE, Alemao E, Solomon DH. Supplementing Claims Data with Electronic Medical Records to Improve Estimation and Classification of Rheumatoid Arthritis Disease Activity: A Machine Learning Approach. ACR Open Rheumatology. 2019 Sep 4. doi: 10.1002/acr2.11068. Abstract

Hejblum BP, Weber GM, Liao KP, Palmer NP, Churchill S, Shadick NA, Szolovits P, Murphy SN, Kohane IS, Cai T. Probabilistic record linkage of de-identified research datasets with discrepancies using diagnosis codes. Sci Data. 2019 Jan 8;6:180298. doi: 10.1038/sdata.2018.298. PMID: 30620344; PMCID: PMC6326114. Abstract

Huang S, He X, Doyle TJ, Zaccardelli A, Marshall AA, Friedlander HMaura, Blaustein RB, Smith EA, Cui J, Iannaccone CK, Mahmoud TG, Weinblatt ME, Dellaripa PF, Shadick NA, Sparks JA. Association of rheumatoid arthritis-related autoantibodies with pulmonary function test abnormalities in a rheumatoid arthritis registry. Clinical Rheumatology. 2019 Jul 31. doi: 10.1007/s10067-019-04733-9. Abstract

Shadick NA, Katz P, Iannaccone CK, Maica G, Coblyn J, Weinblatt ME, Cui J. The Impact of Exercise, Lifestyle, and Clinical Factors on Perceived Cognitive Function in Patients with Rheumatoid Arthritis: Results from a Prospective Cohort Study. ACR Open Rheumatology. 2019 Oct 24. doi: 10.1002/acr2.11088. Abstract

Shadick NA, Gerlanc NM, Frits ML, Stolshek BS, Brady BL, Iannaccone C, Collier D, Cui J, Mutebi A, Weinblatt M. The longitudinal effect of biologic use on patient outcomes (disease activity, function, and disease severity) within a rheumatoid arthritis registry. Clinical Rheumatol. 2019 Jul 29. doi: 10.1007/s10067-019-04649-4 [Epub ahead of print]. Abstract

Sparks JA, He X, Huang J, Fletcher EA, Zaccardelli A, Friedlander HM, Gill RR, Hatabu H, Nishino M, Murphy DJ, Iannaccone CK, Mahmoud TG, Frits ML, Lu B, Rosas IO, Dellaripa PF, Weinblatt ME, Karlson EW, Shadick NA, Doyle TJ. Rheumatoid Arthritis Disease Activity Predicting Incident Clinically Apparent Rheumatoid Arthritis-Associated Interstitial Lung Disease: A Prospective Cohort Study. Arthritis Rheumatol. 2019 Apr 5. doi: 10.1002/art.40904. [Epub ahead of print]. Abstract

Sparks JA, Doyle TJ, Xintong H, Pan B, Iannaccone C, Frits ML, Dellaripa PF, Rosas IO, Lu B, Weinblatt ME, Shadick NA, Karlson EW. Incidence and Predictors of Dyspnea on Exertion in a Prospective Cohort of Patients with Rheumatoid Arthritis. ACR Open Rheumatology. 2019 March. doi: 10.1002/acr2.1001. Abstract

Sung YK, Yoshida K, Prince FHM, Frits ML, Cho SK, Choe JY, Lee HS, Lee J, Lee SS, Yoo DH, Helfgott S, Shadick NA, Weinblatt ME, Solomon DH, Bae SC. Prevalence and predictors for sustained remission in rheumatoid arthritis. PLOS. 2019 Apr 19. doi: 10.1371/journal.pone.0214981. Abstract

Yang N, Huang J, Frits M, Iannaccone C, Weinblatt ME, Rifai N, Shadick N, Bradwin G, Liao KP. Interference of tumor necrosis factor inhibitor treatments on soluble tumor necrosis factor receptor 2 levels in rheumatoid arthritis. Elsevier. 2019 Apr 17. doi: 10.1016/j.plabm.2019.e00122. Abstract

Traylor M, Knevel R, Cui J, Taylor J, Harm-Jan W, Conaghan PG, Cope AP, Curtis C, Emery P, Newhouse S, Patel H, Steer S, Gregersen P, Shadick NA, Weinblatt ME, Van Der Helm-Van Mil A, Barrett JH, Lewis CM, Scott IC. Genetic associations with radiological damage in rheumatoid arthritis: Meta-analysis of seven genome-wide association studies of 2,775 cases. PLOS One. 2019 Oct 9. doi: 10.1371/journal.pone.0223246. Abstract

2018

Ahmad HA, Alemao E, Guo Z, Iannaccone CK, Frits ML, Weinblatt M, Shadick NA. Association of Low Bone Mineral Density with Anti-Citrullinated Protein Antibody Positivity and Disease Activity in Established Rheumatoid Arthritis: Findings from a US Observational Cohort. Adv Ther. 2018 Feb;35(2):232-242. doi: 10.1007/s12325-017-0657-x. Epub 2018 Jan 25. Abstract

Yu Z, Yang N, Everett BM, Frits M, Iannaccone C, Coblyn J, Weinblatt M, Shadick N, Solomon DH, Liao KP. Impact of changes in inflammation on estimated 10-year cardiovascular risk in rheumatoid arthritis. Arthritis Rheumatol. 2018 Apr 20. doi: 10.1002/art.40532. [Epub ahead of print]. Abstract

Shadick NA, Zibit MJ, Iannaccone CK, Thrower R, Sowell NF, Weinblatt ME, Solomon DH, Cui J. A Development and Feasibility Study of a Peer Support Telephone Program in Rheumatoid Arthritis. J Clin Rheumatol. 2018;24(6):346-349. doi:10.1097/RHU.0000000000000661. Full Text.

2017

Alemao E, Guo Z, Frits ML, Iannaccone CK, Shadick NA, Weinblatt ME. Association of anti-cyclic citrullinated protein antibodies, erosions, and rheumatoid factor with disease activity and work productivity: A patient registry study. Semin Arthritis Rheum. 2017 Oct 13 [Epub ahead of print] Abstract

Bermas BL, Tedeschi SK, Frits M, Shadick NA. An evaluation of the patient-administered Rheumatoid Arthritis Disease Activity Index for assessing disease activity during pregnancy. Rheumatology (Oxford). 2017 Dec 1;56(12):2237-2239. Abstract

Solomon DH, Shadick NA, Weinblatt ME, Zak A, Frits M, Franklin JM. Drug safety analyses in a rheumatoid arthritis registry: application of different approaches regarding timing of exposure and confounder measurement. Arthritis Res Ther. 2017 Jun 13;19(1):130. Abstract

Quinn T, Bs MF, von Heideken J, Iannaccone C, Shadick NA, Weinblatt M, Iversen MD. Validity of the Nurses’ health study physical activity questionnaire in estimating physical activity in adults with rheumatoid arthritis. BMC Musculoskelet Disord. 2017 May 31;18(1):234. Abstract

Solomon DH, Shadick NA, Weinblatt ME, Frits M, Iannaccone C, Zak A, Korzenik JR. Clinical patient registry recruitment and retention: a survey of patients in two chronic disease registries. BMC Med Res Methodol. 2017 Apr 17;17(1):59. Abstract

Tedeschi SK, Frits M, Cui J, Zhang ZZ, Mahmoud T, Iannaccone C, Lin T-C, Yoshida K, Weinblatt ME, Shadick NA, Solomon DH. Diet and Rheumatoid Arthritis Symptoms: Survey Results From a Rheumatoid Arthritis Registry. Arthritis Care & Research. 2017 [epub ahead of print]. Abstract

Kim H, Cui J, Frits M, Iannaccone C, Coblyn J, Shadick NA, Weinblatt ME, Lee YC. Fibromyalgia Predicts Two-Year Changes in Functional Status in Rheumatoid Arthritis Patients. Arthritis Care Res (Hoboken). 2017 Feb 9. Abstract

2016

Iversen MD, Frits M, von Heideken J, Cui J, Weinblatt M, Shadick NA. Physical Activity and Correlates of Physical Activity Participation Over Three Years in Adults with Rheumatoid Arthritis. Arthritis Care Res (Hoboken). 2016 Nov 18. Abstract

Radner H, Yoshida K, Tedeschi S, Studenic P, Frits M, Iannaccone C, Shadick NA, Weinblatt M, Aletaha D, Smolen JS, Solomon DH. Different Rating of Global Rheumatoid Arthritis (RA) Disease Activity in Multimorbid Patients with RA. Arthritis Rheumatol. 2016 Nov 11. Abstract

Desai RJ, Solomon DH, Shadick N, Iannaccone C, Kim SC. Identification of smoking using Medicare data – a validation study of claims based algorithims. Pharmacoepidemiol Drug Saf. 2016 Apr;25(4):472-5. Abstract

2015

Liao KP, Playford MP, Frits M, Coblyn JS, Iannaccone C, Weinblatt ME, Shadick NA, Mehta NN. The association between reduction in inflammation and changes in lipoprotein levels and HDL cholesterol efflux capacity in rheumatoid arthritis. J Am Heart Assoc. 2015 Jan 30;4(2). Abstract

Doyle TJ, Patel AS, Hatabu H, Nishino M, Wu G, Osorio JC, Golzarri MF, Traslosheros A, Chu SG, Frits ML, Iannaccone CK, Koontz D, Fuhrman C, Weinblatt ME, El-Chemaly SY, Washko GR, Hunninghake GM, Choi AM, Dellaripa PF, Oddis CV, Shadick NA, Ascherman DP, Rosas IO. Detection of Rheumatoid Arthritis-Interstitial Lung Disease is Enhanced by Serum Biomarkers. Am J Respir Crit Care Med. 2015 Mar 30. Abstract

Michaud K, Strand V, Shadick NA, Degtiar I, Ford K, Michalopolous SN, Hornberger J. Outcomes and costs of incorporating a multibiomarker disease activity test in the management of patients with rheumatoid arthritis. Rheumatology (Oxford).2015 [Epub ahead of print]. Abstract

Desai RJ, Solomon DH, Weinblatt ME, Shadick N, Kim SC. An external validation study reporting poor correlation between the claims-based index for rheumatoid arthritis severity and the disease activity score. Arthritis Res Ther. 2015 Apr 13;17(1):83. Abstract

Iversen MD, Scanlon L, Frits M, Shadick NA, Sharby N. Perceptions of physical activity engagement among adults with rheumatoid arthritis and rheumatologists. Int J Clin Rheumatol. 2015;10(2):67-77. Abstract

Radner H, Yoshida K, Frits M, Iannaccone C, Shadick NA, Weinblatt M, Smolen JS, Solomon DH. The impact of multimorbidity status on treatment response in rheumatoid arthritis patients initiating disease-modifying anti-rheumatic drugs. Rheumatology (Oxford). 2015 Jul 10. Abstract

Radner H, Yoshida K, Mjaavatten MD, Aletaha D, Frits M, Lu B, Iannaccone C, Shadick N, Weinbaltt M, Hmamouchi I, Dougados M, Smolen JS, Solomon DH. Development of a multimorbidity index: Impact on quality of life using a rheumatoid arthritis cohort. Semin Arthritis Rhem. 2015 Jun 19. Abstract

Alemao E, Joo S, Kawabata H, Al MJ, Allison PD, Rutten-Van Molken MP, Frits ML, Iannaccone CK, Shadick NA, Weinblatt ME. Effects of Achieving Target Measures in RA on Functional Status, Quality of Life and Resource Utilization: Analysis of Clinical Practice Data. Arthritis Care Res (Hoboken). 2015 Aug 3. Abstract

Lee SB, Zak A, Iversen MD, Polletta VL, Shadick NA, Solomon DH. Participation in clinical research registries: A focus group examining views from patients with arthritis and other chronic illnesses. Arthritis Care Res (Hoboken). 2015 Oct 16. Abstract

Lee YC, Hackett J, Frits M, Iannaccone CK, Shadick NA, Weinblatt ME, Segurado OG, Sasso EH. Multibiomarker disease acitivity score and C-reactive protein in a cross-sectional observational study of patients with rheumatoid arthritis with and without concomitant fibromyalgia. Rheumatology (Oxford). 2015. Nov 25. Abstract

2014

Desai SP, Liu CC, Tory H, Norton T, Frits M, Lillegraven S, Weinblatt M, Coblyn J, Yazdany J, Shadick N, Solomon DH. Rheumatoid arthritis quality measures and radiographic progression.Semin Arthritis Rheum. 2014 Jan 25. pii: S0049-0172(14)00004-3. doi: 10.1016/j.semarthrit.2014.01.003. [Epub ahead of print] Abstract

Lee YC, Frits ML, Iannaccone CK, Weinblatt ME, Shadick NA, Williams DA, Cui J. Subgrouping of patients with rheumatoid arthritis based on pain, fatigue, inflammation and psychosocial factors. Arthritis Rheumatol. 2014 Aug;66(8): 2006-14. doi: 10.1002/art.38682. PMID:24782222 [PubMed – in process] Abstract

Gillet VG, Solomon DH, Shadick NA, Weinblatt ME, Iannaccone SK, Feldman S, Kim SC. Behavioral and Clinical Factors Associated with Self-Reported Abnormal Papanicolaou Tests in Rheumatoid Arthritis. Womens Health (Larchmt). 2014 Sep;23(9):771-776. PMID:25203494 [PubMed – as supplied by publisher] Abstract

Mjaavatten MD, Radner H, Yoshida K, Shadick NA, Frits ML, Iannaccone CK, Kvien TK, Weinblatt ME, Solomon DH. Do rheumatologists know best? An outcomes study of inconsistent users of disease-modifying anti-rheumatic drugs. Semin Arthritis Rheum. 2014 Aug 27. pii: S0049-0172(14)00185-1.doi:10.1016/j.semarthrit.2014.08.003. [Epub ahead of print] Abstract

Brown LE, Frits ML, Iannaccone CK, Weinblatt ME, Shadick NA, Liao KP. Clinical characteristics of RA patients with secondary SS and association with joint damage. Rheumatology (Oxford). 2014 Oct 13. Pil: keu400. [Epub ahead of print] Abstract

Mjaavatten MD, Radner H, Yoshida K, Shadick NA, Frits ML, Iannaccone CK, Kvien TK, Weinblatt ME, Solomon DH. Inconsistent Treatment with Disease-modifying Antirheumatic Drugs: A Longitudinal Data Analysis. J Rheumatol. 2014 Oct 15. Pil: jrheum.140306. [Epub ahead of print] Abstract

2013

Lu B, Rho YH, Cui J, Iannaccone CK, Frits ML, Karlson EW, Shadick NA. Associations of Smoking and Alcohol Consumption with Disease Activity and Functional Status in Rheumatoid Arthritis. J Rheumatol. 2013 Dec 1. [Epub ahead of print] Abstract

Doyle TJ, Dellaripa PF, Batra K, Frits ML, Iannaccone CK, Hatabu H, Nishino M, Weinblatt ME, Ascherman DP, Washko GR, Hunninghake GM, Choi AM, Shadick NA, Rosas IO. Functional Impact of a Spectrum of Interstitial Lung Abnormalities in Rheumatoid Arthritis. Chest. 2013 Dec 5. doi: 10.1378/chest.13-1394. [Epub ahead of print] Abstract

Cui J, Taylor KE, Lee YC, Källberg H, Weinblatt ME, Coblyn JS, Klareskog L, Criswell LA, Gregersen PK, Shadick NA, Plenge RM, Karlson EW. The influence of polygenic risk scores on heritability of anti-CCP level in RA. Genes Immun. 2014 Jan 2. doi: 10.1038/gene.2013.68. [Epub ahead of print] Abstract

Iannaccone CK, Fossel A, Tsao H, Cui J, Weinblatt M, Shadick N. Factors associated with attrition in a longitudinal rheumatoid arthritis registry. Arthritis Care Res (Hoboken). 2013 Jan 17. doi:10.1002/acr.21940. [Epub ahead of print]. Abstract

Lin C, Karlson EW, Canhao H, Miller TA, Dligach D, Chen PJ, Perez RN, Shen Y, Weinblatt ME, Shadick NA, Plenge RM, Savova GK. Automatic prediction of rheumatoid arthritis disease activity from the electronic medical records.
PLoS One 2013; 8 (8) : e69932 Abstract

Shadick NA, Sowell NF, Frits ML, Hoffman SM, Hartz SA, Booth FD, Sweezy M, Rogers PR, Dubin RL, Atkinson JC, Friedman AL, Augusto F, Iannaccone CK, Fossel AH, Quinn G, Cui J, Losina E, Schwartz RC. A Randomized Controlled Trial of an Internal Family Systems-based Psychotherapeutic Intervention on Outcomes in Rheumatoid Arthritis: A Proof-of-Concept Study.
J Rheumatol Aug 2013; Abstract

Centola M, Cavet G, Shen Y, Ramanujan S, Knowlton N, Swan KA, Turner M, Sutton C, Smith DR, Haney DJ, Chernoff D, Hesterberg LK, Carulli JP, Taylor PC, Shadick NA, Weinblatt ME, Curtis JR. Development of a multi-biomarker disease activity test for rheumatoid arthritis.
PLoS One 2013; 8 (4) : e60635. Abstract

Cui J, Stahl EA, Saevarsdottir S, Miceli C, Diogo D, Trynka G, Raj T, Mirkov MU, Canhao H, Ikari K, Terao C, Okada Y, Wedrén S, Askling J, Yamanaka H, Momohara S, Taniguchi A, Ohmura K, Matsuda F, Mimori T, Gupta N, Kuchroo M, Morgan AW, Isaacs JD, Wilson AG, Hyrich KL, Herenius M, Doorenspleet ME, Tak PP, Crusius JB, van der Horst-Bruinsma IE, Wolbink GJ, van Riel PL, van de Laar M, Guchelaar HJ, Shadick NA, Allaart CF, Huizinga TW, Toes RE, Kimberly RP, Bridges SL, Criswell LA, Moreland LW, Fonseca JE, de Vries N, Stranger BE, De Jager PL, Raychaudhuri S, Weinblatt ME, Gregersen PK, Mariette X, Barton A, Padyukov L, Coenen MJ, Karlson EW, Plenge RM. Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis.
PLoS Genet Mar 2013; 9 (3) : e1003394. Abstract

Bykerk, V, Shadick NA, Frits, M, Bingham, C, Jeffery, I, Iannaccone, C, Weinblatt, M, Solomon, DH. Flares in rheumatoid arthritis: Frequency and Management. A report from the BRASS Registry. J Rheum. 2013 (In Press).

2012

Lillegraven S, Paynter N, Prince FHM, Shadick NA, Haavardsholm EA, Frits ML, Iannaccone CK, Kvien TK, Weinblatt ME, Solomon DH. The performance of matrix-based risk models for rapid radiographic progression in BRASS, a cohort of established rheumatoid arthritis patients. Arthritis Care Res (Hoboken). 2012 Oct 8. doi: 10.1002/acr.21870. [Epub ahead of print]. Abstract

Curtis JR, van der Helm-van Mil AH, Knevel R, Huizinga TW, Haney DJ, Shen Y, Ramanujan S, Cavet G, Centola M, Hesterberg LK, Chernoff D, Ford K, Shadick NA, Hamburger M, Fleischmann R, Keystone E, Weinblatt ME. Validation of a novel multi-biomarker test to assess rheumatoid arthritis disease activity. Arthritis Care Res. 2012 Jun 26. [Epub ahead of print]. Abstract

Prince FH, Bykerk VP, Shadick NA, Lu B, Cui J, Frits M, Iannaccone CK, Weinblatt ME, Solomon DH. Sustained rheumatoid arthritis remission is uncommon in clinical practice. Arthritis Res Ther. 2012 Mar 19;14(2):R68. [Epub ahead of print]. Abstract

Ercan A, Cui J, Hazen MM, Batilwalla F, Royle L, Rudd PM, Coblyn JS, Shadick N, Weinblatt ME, Gregersen P, Lee DM, Nigrovic PA. Hypogalactosylation of serum N-glycans fails to predict clinical response to methotrexate and TNF inhibition in rheumatoid arthritis. Arthritis Res Ther. 2012 Mar 5;14(2):R43. [Epub ahead of print]. Abstract

Chang HH, Tai TS, Lu B, Iannaccone C, Cernades M, Weinblatt M, Shadick N, Miaw SC, Ho IC. PTPN22.6, a dominant negative isoform of PTPN22 and potential biomarker of rheumatoid arthritis. PLoS One. 2012;7(3):e33067. Epub 2012 Mar 12. Abstract

2011

Iannaccone C, Lee Y, Cui J, Frits M, Glass R, Plenge R, Solomon D, Weinblatt M, Shadick N. Using genetic and clinical data to understand response to disease modifying anti-rheumatic drug therapy: data from the Brigham and Women’s Hospital Rheumatoid ArthritisSequential Study. Rheumatology (Oxford). 2011 Jan;50(1):40-6. Epub 2010 Sep 16. Abstract

Iversen M, Chabbriya R, Shadick N. Predictors of use of physical therapy services among patients with rheumatoid arthritis. Phys Ther. 2011 Jan;91(1):65-76. Epub 2010 Nov 11. Abstract

Todd DJ, Knowlton N, Amato M, Frank MB, Schur PH, Izailova ES, Roubenoff R, Shadick NA, Weinblatt ME, Centola M, Lee DM. Erroneous augmentation of multiplex assay measurements in patients with rheumatoid arthritis due to heterophilic binding by serum rheumatoid factor. Arthritis Rheum. 2011 Apr;63(4):894-903. Abstract

Lee YC, Cui J, Lu B, Frits ML, Iannaccone CK, Shadick NA, Weinblatt ME,Solomon DH. Pain persists in DAS28 rheumatoid arthritis remission but not in ACR/EULAR remission: a longitudinal observational study.Arthritis Res Ther 2011 Jun8;13(3):R83. Abstract

Liao KP, Weinblatt ME, Cui J, Iannaccone CK, Chibnik LB, Lu B, Coblyn JS, Shadick NA, Solomon DH. Clinical predictors of erosion-free status in rheumatoid arthritis: a prospective cohort study. Rheumatology (Oxford). 2011 Aug;50(8):1473-9. Epub 2011 Mar 29. Abstract

Lillegraven S, Prince FHM, Shadick NA, Bykerk VP, Lu B, Frits ML, Iannaccone CK, Kvien TK, Haavardsholm EA, Weinblatt ME, Solomon DH. Remission and radiographic outcome in rheumatoid arthritis: application of the 2011 ACR/EULAR remission criteria in an observational cohort. Ann Rheum Dis. 2011 Oct 12. [Epub ahead of print]. Abstract

2010

Cui J, Saevarsdottir S, Thomson B, Padyukov L, van der Helm-van Mil AH, Nititham J, Hughes LB, de Vries N, Raychaudhuri S, Alfredsson L, Askling J, Wedrén S, Ding B, Guiducci C, Wolbink GJ, Crusius JB, van der Horst-Bruinsma IE, Herenius M, Weinblatt ME, Shadick NA, Worthington J, Batliwalla F, Kern M, Morgan AW, Wilson AG, Isaacs JD, Hyrich K, BRAGGSS, Seldin MF, Moreland LW, Behrens TW, Allaart CF, Criswell LA, Huizinga TW, Tak PP, Bridges SL Jr, Toes RE, Barton A, Klareskog L, Peter K. Gregersen PK, Karlson EW, Plenge RM. PTPRC rheumatoid arthritis risk allele is also associated with response to anti-TNF therapy. Arthritis Rheum 2010; Mar 22 [Epub ahead of print] Abstract

Simard JF, Stoll ML, Shadick NA, Karlson EW, Solomon DH. Validity of self-report of infections in a longitudinal cohort of patients with rheumatoid arthritis differs by source of report and infection severity. J Clin Epidemiol. 2010, April 27[Epub ahead of print] Abstract

Ercan A, Cui J, Chatterton DE, Deane KD, Hazen MM, Brintnell W, O’Donnell CI, Derber LA, Weinblatt ME, Shadick NA, Bell DA,Cairns E, Solomon DH, Holers VM, Rudd PM, Lee DM IgG Galactosylation aberrancy precedes disease onset, correlates with disease activity and is prevalent in autoantibodies in rheumatoid arthritis. Arthritis Rheum 2010; April 29. Abstract

Stahl EA, Raychaudhuri S, Remmers EF, Xie G, Eyre S, Thomson BP, Li Y, Kurreeman FAS, Zhernakova A, Hinks A, Guiducci C, Chen R, Alfredsson L, Amos CI, Ardlie KG, BIRAC Consortium, Barton A, Bowes J, Brower E, Burtt N, Cantanese JJ, Coblyn J, Coenen MJH, Costenbader KH, Criswell LA, Crusius JBA, Cui J, de Bakker PIW, De Jager PL, Ding B, Emery P, Flynn E, Harrison P, Hocking LJ, Huizinga TWJ, Kastner DL, Ke X, Lee AT, Liu X, Martin P, Morgan AW, Padyuknov L, Posthumus MD, Radstake TRDJ, Reid DM, Seielstad M, Seldin MF, Shadick NA, Steer S, Tak PP, Thomson W, van der Helm-van Mil AHM, van der Horst-Bruinsma IE, van der Schoot CE, van Riel PLCM, Weinblatt, ME, Wilson AG, Wolbink GJ, Wordsworth P, YEAR Consortium, Wijmenga C, Karlson EW, Toes REM, de Vries N, Begovich AB, Worthington J, Siminovitch KA, Gregersen PK, Klareskog L, Plenge RM. Genome Wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. 2010 Nat Genet; Jun;42(6):508-14. Epub 2010 May 9 Abstract

Tan W, Wu H, Zhao J, Derber LA, Lee DM, Shadick NA, Conn DL, Smith EA, Gersuk VH, Nepom GT, Moreland LW, Furst DE, Thompson SD, Jonas BL, Michael Holers V, Glass DN, Chen PP, Bridges SL Jr, Weinblatt ME, Paulus HE, Tsao BP. A functional RANKL polymorphism associated with younger age at onset of rheumatoid arthritis. Arthritis Rheum. 2010 Jun 7. [Epub ahead of print] Abstract

Sullivan MB, Iannaccone C, Cui J, Lu B, Batra K, Weinblatt M, Shadick N. Evaluation of Selected Rheumatoid Arthritis Activity Scores for Office Based Assessment J Rheum. 2010 Dec;37(12):2466-8. Epub 2010 Sep 1.Abstract

Curtis JR, Jain A, Askling J, Bridges L, Carmona L, Dixon W, Finckh A, Hyrich K, Greenberg J, Kremer J, Listing J, Michaud K, Mikuls T, Shadick N, Solomon D, Wolfe F, Zink A. A Comparison of Patient Characteristics and Outcomes in Selected European and U.S. Rheumatoid Arthritis Registries. Semin Arthritis Rheum. 2010 Aug;40(1):2-14.e1.Abstract

2009

Desai SP, Gravallese EM, Shadick NS, Glass R, Cui J, Frits M, Chibnik LB, Maher N, Weinblatt ME, Solomon DH. Hand Bone Mineral Density is Associated with Both Total Hip and Lumbar Spine Bone Mineral Density in Postmenopausal Women with RA. Rheumatology (Oxford) 2010;49:513-9. Abstract

Raychaudhuri S, Thomson BP, Remmers EF, Eyre S, Hinks A, Guiducci C, Catanese JJ, Xie G, Stahl EA, Chen R, Alfredsson L, Amos CI, Ardlie KG; BIRAC Consortium, Barton A, Bowes J, Burtt NP, Chang M, Coblyn J, Costenbader KH, Criswell LA, Crusius JB, Cui J, De Jager PL, Ding B, Emery P, Flynn E, Harrison P, Hocking LJ, Huizinga TW, Kastner DL, Ke X, Kurreeman FA, Lee AT, Liu X, Li Y, Martin P, Morgan AW, Padyukov L, Reid DM, Seielstad M, Seldin MF, Shadick NA, Steer S, Tak PP, Thomson W, van der Helm-van Mil AH, van der Horst-Bruinsma IE, Weinblatt ME, Wilson AG, Wolbink GJ, Wordsworth P; YEAR Consortium, Altshuler D, Karlson EW, Toes RE, de Vries N, Begovich AB, Siminovitch KA, Worthington J, Klareskog L, Gregersen PK, Daly MJ, Plenge RM. Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. Nat Genet. 2009 Dec;41(12):1313-8. Abstract

Solomon DH, Finkelstein JS, Shadick NA, LeBoff MS, Winalski CS, Stedman M, Glass R, Brookhart MA, Weinblatt MW, Gravallese EM. The Relationship Between Focal Erosions and Generalized Osteoporosis in Postmenopausal Women With Rheumatoid Arthritis. Arthritis & Rheumatism. 2009 Abstract

Lee YC, Cui J, Costenbader KH, Shadick NA, Weinblatt ME, Karlson, EW. Investigation of candidate polymorphisms and disease activity in rheumatoid arthritis patients on methotrexate. Rheumatology (Oxford). 2009 Abstract

Stoll ML, Solomon DH, Batra KL, Simard JF, Karlson EW, Dellaripa PF, Weinblatt ME, Glass R, Shadick NA. TNF alpha inhibitors may improve asthma symptoms: a case study of 12 patients with rheumatoid arthritis and asthma. Journal of Clinical Rheumatology (In press) 2009.

Cui J, Taylor KE, DeStefano AL, Criswell LA, Izmailova E, Parker A, Roubenoff R, Plenge RM, Wienblatt ME, Shadick NA, Karlson EW. Genome Wide Association Study of Determinants of Anti-cyclic Citrullinated Peptide. Molecular Medicine. 2009; (In Press).

2008

Raychaudhuri S, Remmers EF, Lee AT, Hackett R, Guiducci C, Burtt NP,Gianniny L, Korman BD, Padyukov L, Kurreeman FAS, Chang M, Catanese JJ, Ding B, Wong S, van der Helm-van Mil AH, Neale B, Coblyn J, Cui J, Tak PP, Wolbink GJ, Crusius JB, van der Horst-Bruinsma IE, Criswell LA, Amos CI, Seldin MF, Kastner DL,Ardlie KG, Alfredsson L, Costenbader KH, Altshuler D, Huizinga TWJ, Shadick NA, Weinblatt ME, de Vries N, Worthington J, Seielstad M, Toes REM, Karlson EW, Begovich AB, Klareskog L, Gregersen PK, Daly PK, Plenge RM. Common variants at CD40 and other loci confer risk of rheumatoid arthritis. Nat Genet. 2008 Oct;40(10):1216-23. Abstract

Johnsen AK, Plenge RM, Butty V, Campbell C, Dieguez-Gonzalez R, Gomez-Reino JJ, Shadick N, Weinblatt M, Gonzalez A, Gregersen PK, Benoist C, Mathis D. A broad analysis of IL1 polymorphism and rheumatoid arthritis.Arthritis Rheum. 2008 Jul;58(7):1947-57. Abstract

Agarwal SK, Glass RJ, Shadick NA, Coblyn JS, Anderson RJ, Maher NE, Weinblatt ME, Solomon DH. Predictors of discontinuation of tumor necrosis factor inhibitors in patients with rheumatoid arthritis. J Rheumatol. 2008 Sep;35(9):1737-44. Abstract

Roubenoff R, Beckman E, Weinblatt, MW, Shadick NA, Gregersen PK. Biological significance of anti-cyclic citrullinated peptide antibody in rheumatoid arthritis. Ann Intern Med 2008; 148 (5):403; author reply 403-4. . Comment

Royle L, Campbell MP, Radcliffe CM, White DM, Harvey DJ, Abrahams JL, Kim YG, Henry GW, Shadick NA, Weinblatt ME, Lee DM, Rudd PM, Dwek RA. HPLC-based analysis of serum N-glycans on a 96-well plate platform with dedicated database software.. Anal Biochem 2008; 376 (1):1-12. . Abstract

2007

Plenge RM, Cotsapas C, Davies L, Price AL, de Bakker PI, Maller J, Pe’er I, Burtt NP, Blumenstiel B, DeFelice M, Parkin M, Barry R, Winslow W, Healy C, Graham RR, Neale BM, Izmailova E, Roubenoff R, Parker AN, Glass R, Karlson EW, Maher N, Hafler DA, Lee DM, Seldin MF, Remmers EF, Lee AT, Padyukov L, Alfredsson L, Coblyn J, Weinblatt ME, Gabriel SB, Purcell S, Klareskog L, Gregersen PK, Shadick NA, Daly MJ, Altshuler D.Two independent alleles at 6q23 associated with risk of rheumatoid arthritis, Nature Genetics, 2007 Oct; [Epub ahead of print] Abstract

Parker A, Izmailova ES, Narang J, Badola S, Le T, Roubenoff R, Ginsburg GS, Maier A, Coblyn JS, Shadick NA, Weinblatt ME Peripheral Blood Expression of Nuclear Factor-?B-Regulated Genes Is Associated with Rheumatoid Arthritis Disease Activity and Responds Differentially to Anti-Tumor Necrosis Factor-? versus Methotrexate, , J Rheumatol 2007 Sep;34(9):1817-22. Epub 2007 Aug 1. Abstract

Karlson EW, Chibnik LB, Cui J, Plenge RM, Glass RJ, Maher NE, Parker A, Roubenoff R, Izmailova E, Coblyn JS, Weinblatt ME, Shadick NA. Associations between HLA, PTPN22, CTLA4 genotypes and RA phenotypes of autoantibody status, age at diagnosis, and erosions in a large cohort study. Ann Rheum Dis. 2007 Jul 31; [Epub ahead of print]? AbstractHeller JE, Shadick NA. Outcomes in rheumatoid arthritis: incorporating the patient perspective.Curr Opin Rheumatol. 2007 Mar;19(2):101-5. Review. Abstract

Shadick NA, Heller JE, Weinblatt ME, Maher NE, Cui J, Ginsburg GS, Coblyn J, Anderson R, Solomon DH, Roubenoff R, Parker A. Opposing effects of the D70 mutation and the shared epitope in HLA-DR4 on disease activity and certain disease phenotypes in rheumatoid arthritis.Ann Rheum Dis. 2007 May 21; [Epub ahead of print] Abstract

Solomon DH, Stedman M, Licari A, Weinblatt ME, Maher N, Shadick N. Agreement between patient report and medical record review for medications used for rheumatoid arthritis: the accuracy of self-reported medication information in patient registries.Arthritis Rheum. 2007 Mar 15;57(2):234-9. Abstract

2006

Benito-Garcia E, Heller JE, Chibnik LB, Maher NE, Matthews HM, Bilics JA, Weinblatt ME, Shadick NA .Dietary caffeine intake does not affect methotrexate efficacy in patients with rheumatoid arthritis. J Rheumatol. 2006 Jul;33(7):1275-81. Abstract

Costenbader KH, Glass R, Cui J, Shadick N. Risk of serious infections and malignancies with anti-TNF antibody therapy in rheumatoid arthritis. JAMA. 2006 Nov 8;296(18):2201; author reply 2203-4. No abstract available. Excerpt

Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet. 2006 Aug;38(8):904-9. Epub 2006 Jul 23. Abstract

Shadick NA, Cook NR, Karlson EW, Ridker PM, Maher NE, Manson JE, Buring JE, Lee IM. C-reactive protein in the prediction of rheumatoid arthritis in women. Arch Intern Med. 2006 Dec 11-25;166(22):2490-4. Abstract

Sato M, Schneeweiss S, Scranton R, Katz JN, Weinblatt ME, Avorn J, Ting G, Shadick NA, Solomon DH. The validity of a rheumatoid arthritis medical records-based index of severity compared with the DAS28. Arthritis Res Ther. 2006;8(3):R57. Epub 2006 Mar 14. Abstract